Autocrine human growth hormone stimulates the tumor initiating capacity and metastasis of estrogen receptor-negative mammary carcinoma cells

作者：Chen Yi Jun; Zhang Xiao; Wu Zheng Sheng; Wang Jing Jing; Lau Amy Yong Chen; Zhu Tao^*; Lobie Peter E

来源：Cancer Letters, 2015, 365(2): 182-189.

DOI：10.1016/j.canlet.2015.05.031

• Human growth hormone
• Mammary carcinoma
• Cancer stem cell
• Tumor initiation
• Metastasis

The oncogenic effects of autocrine human growth hormone (hGH) have been intensively investigated in estrogen receptor-positive mammary carcinoma (ER + MC) cells. We demonstrated herein that autocrine hGH promoted cancer stem cell (CSC)-like properties of estrogen receptor-negative mammary carcinoma (ER-MC) cells in vitro. In xenograft studies, autocrine hGH increased the tumor initiating capacity of ER-MC cells. We also observed that autocrine hGH promoted migration and invasion of ER-MC cells in vitro, and metastasis in vivo. Thus, inhibition of hGH is a potential therapeutic strategy to prevent tumor initiation and metastasis of ER-MC.

• 出版日期2015-9-1
• 单位中国科学院; 中国科学技术大学; 安徽医科大学