Mismatch repair in Gram-positive bacteria

作者：Lenhart Justin S; Pillon Monica C; Guarne Alba; Biteen Julie S; Simmons Lyle A^*

来源：Research in Microbiology, 2016, 167(1): 4-12.

DOI：10.1016/j.resmic.2015.08.006

• Mismatch repair
• MutS
• MutL
• Bacillus subtilis

DNA mismatch repair (MMR) is responsible for correcting errors formed during DNA replication. DNA polymerase errors include base mismatches and extra helical nucleotides referred to as insertion and deletion loops. In bacteria, MMR increases the fidelity of the chromosomal DNA replication pathway approximately 100-fold. MMR defects in bacteria reduce replication fidelity and have the potential to affect fitness. In mammals, MMR defects are characterized by an increase in mutation rate and by microsatellite instability. In this review, we discuss current advances in understanding how MMR functions in bacteria lacking the MutH and Dam methylase-dependent MMR pathway.

• 出版日期2016-1