Autism spectrum disorder model mice: Focus on copy number variation and epigenetics

作者：Nakai Nobuhiro; Otsuka Susumu; Myung Jihwan; Takumi Toru^*

来源：Science China Life Sciences, 2015, 58(10): 976-984.

DOI：10.1007/s11427-015-4891-7

• copy number variations
• DNA methylation
• histone modification
• ASD model mouse

Autism spectrum disorder (ASD) is gathering concerns in socially developed countries. ASD is a neuropsychiatric disorder of genetic origin with high prevalence of 1%-2%. The patients with ASD characteristically show impaired social skills. Today, many genetic studies identify numerous susceptible genes and genetic loci associated with ASD. Although some genetic factors can lead to abnormal brain function linked to ASD phenotypes, the pathogenic mechanism of ASD is still unclear. Here, we discuss a new mouse model for ASD as an advanced tool to understand the mechanism of ASD.

• 出版日期2015-10
• 单位RIKEN