Angiotensin (1-7) reduces the cell volume of swollen cardiac cells and decreases the swelling-dependent chloride current. Implications for cardiac arrhythmias and myocardial ischemia

作者：De Mello Walmor C^*

来源：Peptides, 2010, 31(12): 2322-2324.

DOI：10.1016/j.peptides.2010.08.024

• Cell swelling
• Angiotensin II
• Angiotensin (1-7)
• Swelling-dependent chloride current
• Cardiac arrhythmias
• Myocardial ischemia

The influence of angiotensin II and angiotensin (1-17) on cell volume and on the activation of ionic channels including the swelling-dependent chloride channel was reviewed. Particular emphasis was given to the influence of the balance between the ACE-angiotensin II and of the ACE2-angiotensin (1-7)-Mas receptor axis on heart cell volume regulation and on the swelling-dependent chloride current. The implications for myocardial ischemia and cardiac arrhythmias are discussed.

• 出版日期2010-12