A highly chemo-, regio-, and stereoselective metallacycle-mediated annulation between a conjugated enyne and an ene-diyne

作者：Shalit Zachary A; Micalizio Glenn C^*

来源：ARKIVOC, 2018, 2018(4): 132-138.

DOI：10.24820/ark.5550190.p010.487

• Metallacycle-mediated cross-coupling
• titanium
• chemoselective
• directed C-C bond-formation
• tandem reaction

Alkoxide-directed metal-centered intermolecular [2+2+2] annulation is shown to chemo-, regio-, and stereoselectively engage two polyunsaturated substrates in productive cyclization chemistry. This annulation process is unique in the field, revealing that it is possible to selectively engage three of five pi-systems residing in the coupling partners in initial [2+2+2] reaction, and demonstrating that one of the two remaining pi-systems (the TMS-alkyne) can ultimately serve to simply generate a new metallacyclopentene of great potential value in additional metallacycle-mediated coupling chemistry.
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• 出版日期2018