Glia selectively approach synapses on thin dendritic spines

作者：Medvedev Nikolai; Popov Victor; Henneberger Christian; Kraev Igor; Rusakov Dmitri A^*; Stewart Michael G

来源：Philosophical Transactions of the Royal Society B-Biological Sciences, 2014, 369(1654): 20140047.

DOI：10.1098/rstb.2014.0047

• glia protection
• synapses
• thin spines

This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three-dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine postsynaptic densities are more tightly surrounded by glia. This distinction suggests that diffusion-dependent synapse-glia communication near 'learning' synapses (associated with thin spines) could be stronger than that near 'memory' synapses (associated with larger spines).

• 出版日期2014-10