A rhodamine-based fluorescent probe containing a Se-N bond for detecting thiols and its application in living cells

作者:Tang Bo*; Xing Yanlong; Li Ping; Zhang Ning; Yu Fabiao; Yang Guiwen
来源:Journal of the American Chemical Society, 2007, 129(38): 11666-+.
DOI:10.1021/ja072572q

摘要

Here we report a new rhodamine-based fluorescent probe containing a selenium-nitrogen bond for detecting thiols based on the nucleophilic substitution of sulfhydryl. The probe was successfully applied to the imaging of thiols in both HL-7702 cells and HepG2 cells with high sensitivity and selectivity.