Acute respiratory distress syndrome due to exposure to high-concentration mixture of ethenone and crotonaldehyde

作者：Huang Jun Feng; Zhu Du Ming; Ma Jie Fei; Zhong Ming^*

来源：Toxicology and Industrial Health, 2015, 31(7): 585-587.

DOI：10.1177/0748233713480205

• Acute lung injury
• acute inhalation injury
• corticosteroid
• ARDS
• acute inhalational exposure

Introduction: Acute inhalational exposure leads to rapidly progressive acute respiratory distress syndrome (ARDS). This report is the first one to present a patient with ARDS in relation to long-standing exposure to a high-concentration mixture of ethenone and crotonaldehyde. Case report: A male worker in a chemical plant was accidentally exposed to the mixture of high-concentrated ethenone and crotonaldehyde for 5 min in an open space and worked continuously in the polluted area for approximately 12 h. On admission, he was conscious with the following vital parameters: blood pressure, 151/91 mmHg; pulse rate, 107 beats/min; respiratory rate, 30 breaths/min; temperature, 37.6 C; oxygen saturation, 92% supported by mask saturation 10 L/min; arterial blood gases showed P/F oxygen ratio of less than 200. Physical examination disclosed decreased bilateral vesicular sounds. A chest computed tomography revealed bilateral nonsegmental ground-glass opacities. The patient was mechanically ventilated and treated with corticosteroid. The patient was discharged without any symptoms. Conclusion: Exposure to mixtures of ethenone and crotonaldehyde can cause severe pulmonary injury leading to delayed ARDS.

• 出版日期2015-7
• 单位复旦大学