Androgen Regulates ADAMTS15 Gene Expression in Prostate Cancer Cells

作者：Molokwu Chidi N; Adeniji Olajumoke O; Chandrasekharan Shankar; Hamdy Freddie C; Buttle David J^*

来源：Cancer Investigation, 2010, 28(7): 698-710.

DOI：10.3109/07357907.2010.489538

• Bladder &amp
• prostate cancer
• Gene expression
• Growth factors &amp
• receptor
• Tumor cell biology
• Tumor suppressors

Prostate cancer is a major cause of mortality, largely as a consequence of metastases and transformation to androgen-independent growth. Metalloproteinases are implicated in cancer progression. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are expressed in prostate cancer cells, with ADAMTS-1 and ADAMTS-15 being the most abundant. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene. ADAMTS-15 expression is predictive for survival in breast cancer, and the situation may be similar in prostate cancer, as androgen independence is usually due to aberrant signaling through its receptor.

• 出版日期2010-8