Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

作者：James Eliza; Eggers Paul K; Harvey Alan R; Dunlop Sarah A; Fitzgerald Melinda; Stubbs Keith A; Reston Colin L^*

来源：Organic and Biomolecular Chemistry, 2013, 11(36): 6108-6112.

DOI：10.1039/c3ob41178h

Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3+ head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcunnin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.

• 出版日期2013-9-28