A Rapid Microwave-Assisted Procedure for Easy Access to N-x Polydentate Ligands for Potential Application in alpha-RIT

作者:Mevel Mathieu; Bodio Ewen; Grosjean Sylvain; Montavon Gilles; Meslin Jean Claude; Julienne Karine; Deniaud David*
来源:Synlett, 2010, (8): 1215-1218.
DOI:10.1055/s-0029-1219813

摘要

Heterocycles bearing a hydrazine moiety react with bisaldehydes or bisketones to afford new N-x polydentate ligands suitable for alpha-radioimmunotherapy. We developed a fast and efficient method using microwave-assisted technology to obtain chelators with variable size and number of coordination centers which were fully characterized. The complexation efficiency with astatine will be assessed.

  • 出版日期2010-5