Muscle microvascular blood flow responses in insulin resistance and ageing

作者：Keske Michelle A^*; Premilovac Dino; Bradley Eloise A; Dwyer Renee M; Richards StephenM; Rattigan Stephen

来源：The Journal of Physiology, 2016, 594(8): 2223-2231.

DOI：10.1113/jphysiol.2014.283549

Insulin resistance plays a key role in the development of type2 diabetes. Skeletal muscle is the major storage site for glucose following a meal and as such has a key role in maintenance of blood glucose concentrations. Insulin resistance is characterised by impaired insulin-mediated glucose disposal in skeletal muscle. Multiple mechanisms can contribute to development of muscle insulin resistance and our research has demonstrated an important role for loss of microvascular function within skeletal muscle. We have shown that insulin can enhance blood flow to the microvasculature in muscle thus improving the access of glucose and insulin to the myocytes to augment glucose disposal. Obesity, insulin resistance and ageing are all associated with impaired microvascular responses to insulin in skeletal muscle. Impairments in insulin-mediated microvascular perfusion in muscle can directly cause insulin resistance, and this event can occur early in the aetiology of this condition. Understanding the mechanisms involved in the loss of microvascular function in muscle has the potential to identify novel treatment strategies to prevent or delay progression of insulin resistance and type2 diabetes.

• 出版日期2016-4-15
• 单位河北医科大学