Association of Platelet Aggregation with Lipid Levels in the Japanese Population: the Suita Study

作者：Kameda Sachika^*; Sakata Toshiyuki; Kokubo Yoshihiro; Mitsuguro Mana; Okamoto Akira; Sano Michitaka; Miyata Toshiyuki

来源：Journal of Atherosclerosis and Thrombosis, 2011, 18(7): 560-567.

• LDL cholesterol
• Lipid
• Platelet aggregation
• Platelet count

Aim: Platelets play a pivotal role in atherothrombotic diseases. Platelet aggregability induced by agonists has great interindividual variability; however, the factors influencing platelet aggregability variation have not been characterized in Asia.
Methods: To examine the confounding factors influencing platelet counts and responsiveness to agonists, we measured the platelet counts and platelet aggregability induced by 1.7 mu M adenosine diphosphate (ADP) or 1.7 mu g/mL collagen using a light transmittance aggregometer in the Japanese general population without medication or cardiovascular disease (387 men and 550 women) in the Suita Study.
Results: Platelet counts were negatively correlated with age in both men and women (Spearman's rank correlation coefficient: rs = -0.230 and -0.227; p < 0.01, respectively). In women, platelet counts were correlated negatively with the high-density lipoprotein (HDL) cholesterol level and positively with the low-density lipoprotein (LDL) cholesterol/HDL cholesterol (L/H) ratio (rs = -0.135 and 0.119; p < 0.01, respectively). In women, platelet aggregabilities by ADP and collagen were correlated with age (rs = 0.118 and 0.143; p < 0.01, respectively), and collagen-induced platelet aggregability was correlated with the LDL cholesterol level, the L/H ratio, and the non-HDL cholesterol level (rs = 0.167, 0.172, and 0.185; p < 0.01, respectively). Even after adjustment for age, systolic blood pressure, body mass index, and current smoking and drinking, the association of platelet counts with the L/H ratio in women and associations of collagen-induced platelet aggregability with the L/H ratio and the non-HDL cholesterol level remained.
Conclusion: Examination of platelet counts and platelet aggregability induced by ADP and collagen revealed gender, age and lipid levels as factors influencing inter-individual variability.

• 出版日期2011