Design, Synthesis and Structure of Novel Para-Quinones and their Antibacterial Activity

作者:Pandurangan Komala; Murnaghan Kevin D; Walshe Aurora; Mueller Bunz Helge; Paradisi Francesca; Morgan Grace G*
来源:Chemical Biology & Drug Design, 2011, 78(5): 787-799.
DOI:10.1111/j.1747-0285.2011.01187.x

摘要

Eight new para-quinones and one known analogue have been synthesized from p-chloranil. Five have been structurally characterized by single crystal diffraction, and a range of ligand folding is observed. All nine have been tested for their potency towards Gram(+) S. aureus and Gram(-) E. coli. Quinones 3, 6, 7 and 8 have shown activity towards S. aureus and quinones 3 and 8 also show good activity towards E. coli.

  • 出版日期2011-11