科研之友
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摘要
Transcription factors (TFs) orchestrate cell-fate decisions by programming the expression of many genes, including those of other TFs that further drive lineage specification. C/EBP proteins and glucocorticoid receptor (GR) activate transcription of the master regulator of adipocyte differentiation, PPAR gamma. A study in this issue of The EMBO Journal sheds light on how C/EBPs, GR, STAT5, and RXR cooperate during early adipogenesis to globally remodel the epigenome.
- 出版日期2011-4-20
