Development of a novel chiral spiro ligand bearing oxazoline

作者：Kato T; Marubayashi K; Takizawa S; Sasai H^*

来源：Tetrahedron: Asymmetry , 2004, 15(23): 3693-3697.

DOI：10.1016/j.tetasy.2004.09.037

The synthesis of bis(oxazoline) ligand 1 bearing a spiro skeleton is achieved via double ring-closing metathesis (RCM) of tetraene 2 and subsequent oxazoline ring formation using N-bromosuccinimide (NBS). The Cu-spiro bis(oxazoline) complexes prepared from 1 and Cu(OTf)(2) or Cu(OAc)(2) act efficiently as chiral catalysts for promoting carbonyl-ene reactions or Henry reactions with good enantiocontrol.

• 出版日期2004-11-29