Development and Validation of an Electrochemical Screening Methodology for Sulfonamide Residue Control in Milk Samples Using a Graphene Quantum Dots@Nafion Modified Glassy Carbon Electrode

作者：Gondim Carina S; Duran Gema M; Contento Ana M; Rios Angel^*

来源：Food Analytical Methods, 2018, 11(6): 1711-1721.

DOI：10.1007/s12161-018-1157-6

• Amperometric sensor
• Modified electrode
• Graphene quantum dots
• Screening method
• Sulfonamide residues
• Milk samples

An electrochemical method based on the assembly of graphene quantum dots (GQD) and Nafion onto a glassy carbon electrode (GQD@Nafion/GCE) was developed to detect sulfonamide residues in milk. The resulting modified electrode (GQD@Nafion/GCE) demonstrated a significant increase in sensitivity compared to a bare GCE. Repeatability, reproducibility, and stability studies also indicated the suitability of the electrode used as a sensing probe for sulfonamide residues. Under optimized conditions, the method was validated according to specific performance parameters of screening (qualitative) methods. Six sulfonamides were evaluated: sulfadimethoxine, sulfadiazine, sulfamethazine (SMZ), sulfamethoxypyridazine, sulfapyridine, and sulfathiazole, taking SMZ as the representative analyte in milk samples. No false-positive results were observed, the parameters related to precision presented suitable values, and the detection limit was estimated as 74.8 mu g L-1. The screening method demonstrated its applicability for the analytical control of total sulfonamide residues according to international regulations for maximum residue limits.

• 出版日期2018-6
• 单位中国科学院长春应用化学研究所