An overview of the immune modulating effects of enzymatic toxins from snake venoms

作者：Burin Sandra M; Menaldo Danilo L; Sampaio Suely V; Frantz Fabiani G; Castro Fabiola A^*

来源：International Journal of Biological Macromolecules, 2018, 109: 664-671.

DOI：10.1016/j.ijblomac.2017.12.101

• Snake venoms
• Enzymatic toxins
• Immune system

Snake venoms are complex mixtures of organic and inorganic compounds, including proteins belonging to the protease (serine and metalloproteinases), oxidase (L-amino acid oxidases), and phospholipase (especially phospholipases A(2)) enzyme classes. These toxins account for the serious deleterious effects of snake envenomations, such as tissue necrosis, neurotoxicity, and hemorrhage. In addition to their toxic effects, snake venom toxins have served as important tools for investigating the mechanisms underlying envenomation and discovering new pharmacologically active compounds with immunotherapeutic potential. In this sense, the present review discusses the new findings and therapeutic perspectives in the immune modulating potential of enzymatic toxins from snake venoms belonging to the classes metalloproteinase, serine protease, L-amino acid oxidase, and phospholip'ase A(2).

• 出版日期2018-4