A search for Helicobacter pylori in localized vulvodynia

作者：Geva Adam; Sabo Edmond; Levy Josef; Blumenthal Monique; Ophir Ella; Geva Hana; Bornstein Jacob^*

来源：Gynecologic and Obstetric Investigation, 2008, 66(3): 152-156.

DOI：10.1159/000135712

• localized vulvodynia
• Helicobacter pylori
• peptic disease
• omeprasole
• mast cells

Background: We noted that several patients presenting with both localized vulvodynia (vulvar vestibulitis) and peptic symptoms reported a resolution of dyspareunia after receiving a full treatment course for Helicobacter pylori. Methods: Women with localized vulvodynia were interviewed regarding symptoms of peptic disease. Those with peptic symptoms underwent a blood test for the presence of antibodies to H. pylori and were referred to a gastroenterology consultation. In all women, vestibular biopsies were obtained and stained for H. pylori. Healthy vestibular tissues as well as archival negative and positive gastric tissues served as controls. Results: Of the blood antibody tests, 12 (80%) were positive. None of the patients had evidence of H. pylori in the vestibule. Eleven women received triple therapy for eradication of H. pylori. Eight (73%) reported complete relief of dyspareunia and of gastric symptoms. Conclusion: Our study found no immunohistochemical evidence of H. pylori infection in the vestibule but suggested a possible role for anti-H. pylori treatment in localized vulvodynia.

• 出版日期2008