科研之友
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摘要
The Mitsunobu reaction of N-ethoxycarbonyl-(4R)-hydroxy-(S)-proline methyl ester with phenol afforded (4S)-phenoxy-(S)-proline methyl. ester, which, after saponification and hydrolysis in hydrochloric acid, gave the title amino acid. This compound (5 mol%) catalyzes aldol reaction of acetone with benzaldehydes enantioselectively in the yields ranging from 67.4% to 89.9%, with the ee up to 76.5%.
