Antitubercular and Antibacterial Activity of Quinonoid Natural Products Against Multi-Drug Resistant Clinical Isolates

作者：Dey Diganta; Ray Ratnamala; Hazra Banasri^*

来源：Phytotherapy Research, 2014, 28(7): 1014-1021.

DOI：10.1002/ptr.5090

• Mycobacterium tuberculosis
• quinonoids
• natural products
• multi-drug resistance
• clinical isolates

Multi-drug resistant Mycobacterium tuberculosis and other bacterial pathogens represent a major threat to human health. In view of the critical need to augment the current drug regime, we have investigated therapeutic potential of five quinonoids, viz. emodin, diospyrin, plumbagin, menadione and thymoquinone, derived from natural products. The antimicrobial activity of quinonoids was evaluated against a broad panel of multi-drug and extensively drugresistant tuberculosis (M/XDR-TB) strains, rapid growing mycobacteria and other bacterial isolates, some of which were producers of beta-lactamase, Extended-spectrum beta-lactamase (ESBL), AmpC beta-lactamase, metallo-beta-lactamase (MBL) enzymes, as well as their drug-sensitive ATCC counterparts. All the tested quinones exhibited antimycobacterial and broad spectrum antibacterial activity, particularly against M. tuberculosis (lowest MIC 0.25 mu g/mL) andGram-positive bacteria (lowest MIC %26lt; 4 mu g/mL) of clinical origin. The order of antitubercular activity of the tested quinonoids was plumbagin %26gt; emodin similar to menadione similar to thymoquinone %26gt; diospyrin, whereas their antibacterial efficacy was plumbagin %26gt; menadione similar to thymoquinone %26gt; diospyrin %26gt; emodin. Furthermore, this is the first evaluation performed on these quinonoids against a broad panel of drug-resistant and drug-sensitive clinical isolates, to the best of our knowledge.

• 出版日期2014-7