Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats

作者：Kim In Hee; Kim Dae Ghon^*; Hao Peipei; Wang Yunpeng; Kim Seong Hun; Kim Sang Wook; Lee Seung Ok; Lee Soo Teik

来源：BMB Reports, 2012, 45(6): 348-353.

DOI：10.5483/BMBRep.2012.45.6.276

• L-2-Oxothiazolidine-4-carboxylic acid
• Liver fibrosis
• Nrf2
• Oxidative stress
• Thioacetamide

L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug that maintains glutathione in tissues. The present study was designed to investigate anti-fibrotic and anti-oxidative effects of OTC via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in an in vivo thioacetamide (TAA)-induced hepatic fibrosis model. Treatment with OTC (80 or 160 mg/kg) improved serum liver function parameters and significantly ameliorated liver fibrosis. The OTC treatment groups exhibited significantly lower expression of a-smooth muscle actin, transforming growth factor-beta 1, and collagen alpha 1 mRNA than that in the TAA model group. Furthermore, the OTC treatment groups showed a significant decrease in hepatic malondialdehyde level compared to that in the TAA model group. Nrf2 and heme oxygenase-1 expression increased significantly in the OTC treatment groups compared with that in the TAA model group. Taken together, these results suggest that OTC restores the anti-oxidative system by upregulating Nrf2; thus, ameliorating liver injury and a fibrotic reaction. [BMB Reports 2012; 45(6): 348-353]

• 出版日期2012-6-30