A novel electrochemical chiral interface based on sandwich-structured molecularly imprinted SiO2/AuNPs/SiO2 for enantioselective recognition of cysteine isomers

作者：Zhang, Jie; Tan, Wensheng; Tao, Yongxin; Deng, Linhong; Qin, Yong; Kong, Yong^*

来源：Electrochemistry Communications, 2018, 86: 57-62.

DOI：10.1016/j.elecom.2017.11.016

• Electrochemical chiral interface
• Sandwich structure
• Molecularly imprinted SiO2/AuNPs/SiO2
• Enantioselective recognition
• Cys isomers

SiO2 nanospheres were synthesized by the sol-gel method using tetraethoxysilane (TEOS) as the precursor, which was then modified with 3-aminopropyltriethoxysilane (APTES) for the grafting of -NH2 to the SiO2 surface. Au nanoparticles (AuNPs) were anchored to the -NH2 grafted SiO2, and then L-cysteine (L-Cys) templates were introduced to the SiO2/AuNPs through forming AueS bond. Another layer of SiO2 was then coated on the L-Cys doped SiO2/AuNPs as the coating layer, and then the templates were removed by calcination to form a sandwich-structured molecularly imprinted SiO2/AuNPs/SiO2. Finally, the molecularly imprinted chiral interface was applied for electrochemical enantioselective recognition of Cys isomers, and discernible differences in the current signals could be observed on the differential pulse voltammograms (ID-cys/IL-cys, 2.36).

• 出版日期2018-1
• 单位常州大学