A longitudinal study on alpha-synuclein in blood plasma as a biomarker for Parkinson%26apos;s disease

作者：Foulds Penelope G; Diggle Peter; Mitchell J Douglas; Parker Angela; Hasegawa Masato; Masuda Suzukake Masami; Mann David M A; Allsop David^*

来源：Scientific Reports, 2013, 3(1): 2540.

DOI：10.1038/srep02540

There have been no longitudinal studies on alpha-synuclein as a potential biomarker for the progression of Parkinson%26apos;s disease (PD). Here, blood plasma %26apos;total alpha-synuclein%26apos; and %26apos;Ser-129 phosphorylated alpha-synuclein%26apos; were assayed at 4-6 monthly intervals from a cohort of 189 newly-diagnosed patients with PD. For log-transformed data, plasma total alpha-synuclein levels increased with time for up to 20 yrs after the appearance of initial symptoms (p = 0.012), whereas phosphorylated alpha-synuclein remained constant over this same period. The mean level of phosphorylated alpha-synuclein, but not of total alpha-synuclein, was higher in the PD plasma samples taken at first visit than in single samples taken from a group of 91 healthy controls (p = 0.012). Overall, we conclude that the plasma level of phosphorylated alpha-synuclein has potential value as a diagnostic tool, whereas the level of total alpha-synuclein could act as a surrogate marker for the progression of PD.

• 出版日期2013-8-29
• 单位河北医科大学