Association between induced abortion history and later in vitro fertilization outcomes

作者：Wang, Yao; Sun, Yun; Di, Wen; Kuang, Yan-ping; Xu, Bing^*

来源：International Journal of Gynecology & Obstetrics, 2018, 141(3): 321-326.

DOI：10.1002/ijgo.12481

• Abortion
• Clinical pregnancy rate
• In vitro fertilization
• Live birth rate
• Spontaneous abortion rate

Objective: To establish an effective and safe clinical fertility strategy by investigating the relationship between abortion history and pregnancy outcomes of in vitro fertilization (IVF) treatment. @@@ Methods: In the present retrospective cohort study, data from IVF treatment cycles performed at a reproductive center in China between October 1, 2014, and October 31, 2015, were assessed. Outcomes were compared between women with a history of induced abortion and those without. @@@ Results: There were 1532 IVF treatment cycles included; 454 patients had a history of induced abortion and 1078 did not. The spontaneous abortion rate was significantly higher (30/170 [17.6%] vs 41/420 [9.8%]; P=0.002) and the endometrium was significantly thinner (8.81.8 vs 9.71.8 cm; P=0.001) among patients with a history of induced abortion compared with those without. In a subgroup analysis of patients with a history of induced abortion, women who had undergone surgical abortions had a lower live delivery rate compared with medical abortions (29/76 [38%] vs 101/378 [27%]; P=0.039). Further, women who had a history of more than two surgical abortions had lower live delivery and clinical pregnancy rates (both P<0.05). @@@ Conclusion: A history of induced abortion was associated with worse IVF outcomes, especially a history of more than two surgical abortions.

• 出版日期2018-6
• 单位上海交通大学