Postoperative morbidity after completion surgery following homogeneous chemoradiation therapy in locally advanced cervical cancer

作者：Touboul C^*; Uzan C; Mauguen A; Gouy S; Rey A; Pautier P; Lhomme C; Duvillard P; Haie Meder C; Morice P

来源：Journal de Gynecologie Obstetrique et Biologie de la Reproduction, 2010, 39(8): 624-631.

DOI：10.1016/j.jgyn.2010.09.009

• Completion surgery
• Chemoradiation therapy
• Locally advanced cervical cancer
• Morbidity

Objective - To evaluate the morbidity rate in patients following completion surgery (hysterectomy lymphadenectomy) after chemoradiation therapy (CRT) for an advanced stage cervical cancer
Patients and methods - Patients fulfilling the following inclusion criteria were studied (1) stage IB2 IVA cervical carcinoma, (2) tumor initially confined to the pelvic cavity, (3) pelvic external radiation therapy with delivery of 45 Gy with concomitant chemotherapy (cisplatin 40 mg/m(2)/week) followed by utero vaginal brachytherapy, (4) completion surgery after the end of radiation therapy including at least a hysterectomy
Results - One hundred and fifty patients treated between 1998 and 2007 fulfilled inclusion criteria Thirty seven (25%) patients had 55 post operative complications (17 had severe complications requiring surgical or radiological treatment) Two deaths related to postoperative morbidity had occurred The risk of complications was increased with a radical hysterectomy (OR = 2 4, P = 0 04) and the presence of residual cervical disease (<= 1 cm OR = 4 3, >1 cm OR = 2 5, P = 0 01)
Conclusion - In the present study, the morbidity of completion surgery (based on hysterectomy with or without lymphadenectomy

• 出版日期2010-12