Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

作者：Chen, Shuqiang; Dong, Guoqiang; Wu, Shanchao; Liu, Na; Zhang, Wannian; Sheng, Chunquan^*

来源：Acta Pharmaceutica Sinica B, 2019, 9(1): 144-156.

DOI：10.1016/j.apsb.2018.08.003

• Fluorescent probes
• 10-Hydroxyevodiamine
• Anticancer mechanisms
• Autophagy
• Apoptosis

Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

• 出版日期2019-1
• 单位中国人民解放军第二军医大学