Antidepressant effects of methanol extract and fractions of Bacopa monnieri

作者：Shen, Yun-Heng; Zhou, Yun; Zhang, Chuan; Liu, Run-Hui; Su, Juan; Liu, Xiao-Hua; Zhang, Wei-Dong^*

来源：Pharmaceutical Biology, 2009, 47(4): 340-343.

DOI：10.1080/13880200902752694

• Bacopa monniera
• forced swimming test (FST)
• tail suspension test (TST)
• antidepressant activity

Bacopa monniera (L.) Wettst (Scrophulariaceae), a reputed Ayurvedic medicinal plant of India, has been widely used as a brain tonic for centuries. In the present study, the methanol extract and different fractions of B. monniera were evaluated for antidepressant activity in the forced swimming test (FST) and tail suspension test (TST) in mice. The results showed that the methanol extract, EtOAc fraction, and n-BuOH fraction significantly reduced the immobility times both in FST and TST in mice after being administrated orally for 5 consecutive days. All tested samples, in the effective doses for FST and TST, showed no inhibitory effect against locomotor activity (LA) in mice.

• 出版日期2009-4
• 单位中国人民解放军第二军医大学; 上海交通大学