Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis

作者：Higuchi Wataru; Hung Wei Chun; Takano Tomomi; Iwao Yasuhisa; Ozaki Kyoko; Isobe Hirokazu; Teng Lee Jene; Shimazaki Tetsuya; Honda Akihito; Higashide Masato; Hanaki Hideaki; Yamamoto Tatsuo^*

来源：Journal of Infection and Chemotherapy, 2010, 16(2): 144-149.

DOI：10.1007/s10156-010-0029-9

• Cellulitis
• Child
• Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)
• Panton-Valentine leucocidin (PVL)

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which often produces Panton-Valentine leucocidin (PVL), has emerged worldwide as a life-threatening pathogen. Herein, we describe molecular characteristics of MRSA isolated from abdominal cellulitis in a 7-year-old Japanese boy. This MRSA was PVL-positive and belonged to the Taiwanese multiple drug-resistant CA-MRSA clone with the genotype of ST59, staphylococcal cassette chromosome mec (SCCmec) VII (SCCmecV, according to recent reclassification), agr1a (a novel agr1 subtype), and SaPI (which carried seb1, a newly designated variant seb gene). This study demonstrates the first isolation of the Taiwanese PVL-positive ST59 MRSA clone in Japan. The data also demonstrate novel subtypes in agr1 and seb and suggest that a combination of agr1a, seb1, and PVL could contribute to cellulitis (and its recurrence). Recently, a variety of PVL-positive MRSA clones are accumulating in Japan.

• 出版日期2010-4