摘要

Heterocyclic compounds have shown many excellent biological activities in both area of medicine and pesticide. The synthetic method is one of the focused fields concerning pharmaceutical and pesticidal researches at present. With the theme of green synthesis, some advantadges of organic solvent-free heterocyclic synthesis in high yield, good selectivity, easy operation, low cost and environmental friendship were introduced. And the developments in the recent four years of solvent-free reaction in heterocyclic synthesis study have been reviewed.