A Smooth Muscle-Like Origin for Beige Adipocytes

作者：Long Jonathan Z; Svensson Katrin J; Tsai Linus; Zeng Xing; Roh Hyun C; Kong Xingxing; Rao Rajesh R; Lou Jesse; Lokurkar Isha; Baur Wendy; Castellot John J Jr; Rosen Evan D; Spiegelman Bruce M^*

来源：Cell Metabolism, 2014, 19(5): 810-820.

DOI：10.1016/j.cmet.2014.03.025

Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal profiling approach, we present a comprehensive molecular description of brown and beige gene expression from multiple fat depots in vivo. This UCP1-TRAP data set demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown, adipocytes. In vivo fate mapping using either a constitutive or an inducible Myh11-driven Cre demonstrates that at least a subset of beige cells arise from a smooth muscle-like origin. Finally, ectopic expression of PRDM16 converts bona fide vascular smooth muscle cells into Ucp1-positive adipocytes in vitro. These results establish a portrait of brown and beige adipocyte gene expression in vivo and identify a smooth muscle-like origin for beige cells.

• 出版日期2014-5-6