Analysis of IL-6, IL-10, IL-17 levels in the blood of patients with chronic hepatitis B

作者：Ming, De-Song^*; Lin, Zhen-Zhong; Qiu, Xiao-Dong

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(6): 9437-9442.

• HBV
• IL-6
• IL-10
• IL-17

Objective: To investigate the role and significance of serum IL-6, IL-10, IL-17 in the occurrence and development of chronic hepatitis B. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-6, IL-10, IL-17 levels and liver function in patients with hepatitis B and relationship between serum viral load in 70 cases of CHB patients and 20 healthy subjects (control group). Results: Compared with healthy controls, IL-6, IL-10, IL-17 in CHB patients were significantly increased (P < 0.05); compared with HBeAg negative patients, IL-6 levels were decreased in HBeAg positive group (P < 0.05), while IL-17 levels were significantly increased (P < 0.05) and there was no significant difference in the level of IL-10; three kinds of cytokine levels did not show difference between HBV-DNA >= 105 copies/ml and <105 copies/ml(2) group; IL-6 was positively correlated with AST, TBIL, HBV-DNA. Conclusion: IL-6, IL-10, IL-17 are involved in the pathogenesis of CHB, the change of its content is closely related to the degree of liver inflammation and viral replication.

• 出版日期2016
• 单位福建医科大学