Analysis of lymphocyte subgroups in Crimean-Congo hemorrhagic fever

作者：Akinci Esraguel^*; Yilmaz Mesude; Bodur Huerrem; Onguru Pinar; Bayazit Fatma Nurhayat; Erbay Ayse; Ozet Gulsum

来源：International Journal of Infectious Diseases, 2009, 13(5): 560-563.

DOI：10.1016/j.ijid.2008.08.027

• Crimean-Congo hemorrhagic fever
• Lymphocyte subgroups
• T Lymphocytes

Objectives: This study examined the association between lymphocyte subgroups and mortality in patients with Crimean-Congo hemorrhagic fever (CCHF) in Turkey.
Methods: During the spring and summer of 2007, peripheral blood was collected from hospitalized patients with suspected CCHF. Lymphocyte subgroups were characterized by fluorescence-activated cell sorting. CCHF cases were confirmed by detecting viral RNA by PCR and/or IgM antibodies by ELISA. Lymphocyte subgroups were compared between fatal and non-fatal cases. The correlation between lymphocyte subgroups and viral loads was also investigated.
Results: Seventy-seven confirmed cases of CCHF were included in this study (five cases were fatal (6.5 %)). No differences in lymphocyte subgroups were found between fatal and non-fatal cases, except for significantly higher CD3+CD8+ T cells in the fatal cases (p = 0.017). A positive correlation between viral toad and CD3+CD8+ T cells was also detected (p = 0.044). There was no correlation between other lymphocyte subgroups and viral load.
Conclusions: Higher levels of CD3+CD8+ T lymphocytes were detected in fatal compared to non-fatal CCHF cases. Despite this cytotoxic immune activation, a fatal outcome could not be prevented. We hypothesize that high viral load and other factors may influence this outcome, although more studies are required to explain the pathogenesis of CCHF.

• 出版日期2009-9