A mathematical model of P53 gene regulatory networks under radiotherapy

作者：Qi, J. P.^*; Shao, S. H.; Xie, Jinli; Zhu, Y.

来源：Biosystems, 2007, 90(3): 698-706.

DOI：10.1016/j.biosystems.2007.02.007

• P53
• gene regulatory networks
• radiotherapy
• DNA damage
• oscillations

P53, a vital anticancer gene, controls the transcription and translation of a series of genes, and implement the cell cycle arrest and cell apoptosis by regulating their complicated signal pathways. Under radiotherapy, cell can trigger internal self-defense mechanisms in fighting against genome stresses induced by acute ion radiation (IR). To simulate the investigating of cellular responding acute IR at single cell level further, we propose a model of P53 gene regulatory networks under radiotherapy. Our model can successfully implement the kinetics of double strand breaks (DSBs) generating and their repair, ataxia telangiectasia. mutated (ATM) activation, as well as P53-MDM2 feedback regulating. By comparing simulations under different IR dose, we can try to find the optimal strategy in controlling of IR dose and therapy time, and provide some theoretical analysis to obtain much better outcome of radiotherapy further.

• 出版日期2007-12
• 单位东华大学