Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis: A Cross-Sectional Study in a Mexican Population

作者：Gomez Banuelos Eduardo; Teresita Martin Marquez Beatriz; Aurora Martinez Garcia Erika; Figueroa Sanchez Mauricio; Nunez Atahualpa Lourdes; Daniel Rocha Munoz Alberto; Ernesto Sanchez Hernandez Pedro; Elena Navarro Hernandez Rosa; Monserrat Madrigal Ruiz Perla; Alberto Saldana Millan Adan; Duran Barragan Sergio; Gonzalez Lopez Laura; Ivan Gamez Nava Jorge; Vazquez Del Mercado Monica^*

来源：Biomed Research International, 2014, 2014: 736786.

DOI：10.1155/2014/736786

Patients with rheumatoid arthritis (RA) have a higher risk for atherosclerosis. There is no clinical information about scavenger receptor CD36 and the development of subclinical atherosclerosis in patients with RA. The aim of this study was to evaluate the association between membrane expression of CD36 in peripheral blood mononuclear cells (PBMC) and carotid intima-media thickness (cIMT) in patients with RA. Methods. We included 67 patients with RA from the Rheumatology Department of Hospital Civil "Dr. Juan I. Menchaca," Guadalajara, Jalisco, Mexico. We evaluated the cIMT, considering subclinical atherosclerosis when >0.6 mm. Since our main objective was to associate the membrane expression of CD36 with subclinical atherosclerosis, other molecules related with cardiovascular risk such as ox-LDL, IL-6, and TNF alpha were tested. Results. We found low CD36 membrane expression in PBMC from RA patients with subclinical atherosclerosis (p < 0.001). CD36 mean fluorescence intensity had negative correlations with cIMT (r - -0.578, p < 0.001), ox-LDL (r - -0.427, P - 0.05), TNF alpha (r - -0.729, p < 0.001), and IL-6 (r - -0.822, p < 0.001). Conclusion. RA patients with subclinical atherosclerosis showed low membrane expression of CD36 in PBMC and increased serum proinflammatory cytokines. Further studies are needed to clarify the regulation of CD36 in RA.

• 出版日期2014