A single-loop fiber attenuated total reflection sensor enhanced by silver nanoparticles for continuous glucose monitoring

作者：Li Dachao^*; Sun Yanwen; Yu Songlin; Sun Changyue; Yu Haixia; Xu Kexin

来源：Sensors and Actuators B: Chemical , 2015, 220: 1033-1042.

DOI：10.1016/j.snb.2015.06.028

• Continuous glucose monitoring
• Fiber ATR sensors
• Single-loop structure
• Silver nanoparticles
• Surface enhanced IR absorption

Currently, the implantable enzyme electrode sensor is the only method for continuous glucose monitoring in clinical applications, but the significant drift caused by bioelectricity in body and the effect of electrochemical reactions under hypoxia reduce the accuracy of the glucose measurements. Therefore, finger-prick blood corrections are often required to calibrate enzyme-based glucose sensors several times each day. In this paper, we proposed an implantable miniaturized fiber Attenuated Total Reflection (ATR) sensor based on mid-infrared spectroscopy to overcome the two drawbacks. A single-loop structure of fiber ATR sensor was used to increase the effective optical length to enhance the sensitivity. By growing silver nanoparticles (AgNPs) on the cylindrical surface of the fiber ATR sensor with a chemical silver mirror method, the sensitivity of the infrared absorption signal was further enhanced. In the experiment, the fiber ATR sensor enhanced by AgNPs combined with a CO2 laser showed an intense absorption signal from glucose, with enhancement factors of two to six folds at different absorption wavenumbers compared with the bare fiber ATR sensors. The prediction of glucose concentration with high accuracy was achieved by using the five-variable partial least-squares model yielding a root-mean-square error of prediction as small as 4.45 mg/dL.

• 出版日期2015-12-1
• 单位天津大学