Tolerogenic Dendritic Cell-Regulatory T-cell Interaction and the Promotion of Transplant Tolerance

作者：Thomson Angus W^*; Turnquist Heth R; Zahorchak Alan F; Raimondi Giorgio

来源：Transplantation, 2009, 87(9): S86-S90.

DOI：10.1097/TP.0b013e3181a2dcec

• Dendritic cells
• Regulatory T cells
• Transplantation
• Tolerance

Evidence has accumulated that targeting of donor alloantigen to quiescent dendritic cells (DC) in situ or adoptive DC therapy is associated with the expansion or induction of regulatory T cells (Treg) in experimental organ transplantation. These Treg can mediate suppression of antidonor T-effector cell responses and promote allograft tolerance. In addition, Treg can exert reciprocal, inhibitory effects on DC that maintain their tolerogenic properties. Several groups have exploited DC to expand allo-Ag-specific Treg in vitro, followed by adoptive transfer of the Treg to graft recipients, an approach that holds promise for tolerogenic cell therapy in clinical cell and organ transplantation.

• 出版日期2009-5-15