Fabrication of micro-alginate gel tubes utilizing micro-gelatin fibers

作者：Sakaguchi Katsuhisa; Arai Takafumi; Shimizu Tatsuya; Umezu Shinjiro^*

来源：Japanese Journal of Applied Physics, 2017, 56(5): 05EB06.

DOI：10.7567/JJAP.56.05EB06

• Alginate gel
• Bioengineered tissue
• Biofabrication
• Gelatin fibers
• Lymphatic vessels
• Micro-tubular
• Quality of life

Tissues engineered utilizing biofabrication techniques have recently been the focus of much attention, because these bioengineered tissues have great potential to improve the quality of life of patients with various hard-to-treat diseases. Most tissues contain micro-tubular structures including blood vessels, lymphatic vessels, and bile canaliculus. Therefore, we bioengineered a micro diameter tube using alginate gel to coat the core gelatin gel. Micro-gelatin fibers were fabricated by the coacervation method and then coated with a very thin alginate gel layer by dipping. A micro diameter alginate tube was produced by dissolving the core gelatin gel. Consequently, these procedures led to the formation of micro-alginate gel tubes of various shapes and sizes. This biofabrication technique should contribute to tissue engineering research fields.

• 出版日期2017-5