Update on PEG-Interferon alpha-2b as Adjuvant Therapy in Melanoma

作者：Di Trolio Rossella; Simeone Ester; Di Lorenzo Giuseppe; Grimaldi Antonio Maria; Romano Anna; Ayala Fabrizio; Caraco Corrado; Mozzillo Nicola; Ascierto Paolo A^*

来源：Anticancer Research, 2012, 32(9): 3901-3909.

• PEG-Interferon alpha-2b
• melanoma
• adjuvant therapy
• review

Based on the results of European Organization for Research and Treatment of Cancer (EORTC) 18991 trial, the US Food and Drug Administration (FDA) approved PEG-interferon alpha-2b (PEG-IFN) (Sylatron) as adjuvant therapy for high-risk melanoma. The EORTC 18991 trial was an open-label study of resectable stage III melanoma with 1,256 patients who were randomized to observation-alone or to treatment with PEG-IFN for up to 5 years. The median recurrence-free survival of the treatment groups was significantly longer, while overall survival, a secondary endpoint, was not significantly different between the two groups. This review, after a short summary of interferon alpha-2b trials, critically analyzes the EORTC18991 trial, as well as the subgroup results and future perspectives for this stage of disease.

• 出版日期2012-9