Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N-Heterocyclic Carbenes Derived from (S)-Pyroglutamic Acid

作者：Aupoix Audrey; Bournaud Chloee; Vo Thanh Giang^*

来源：European Journal of Organic Chemistry, 2011, (15): 2772-2776.

DOI：10.1002/ejoc.201100100

• Asymmetric catalysis
• Hydrogenation
• Carbene ligands
• Ketones
• Rhodium

A new and flexible procedure for the preparation of chiral azolium salts derived from (S)-pyroglutamic acid has been developed. The efficiency of these ligands has been evaluated in the metal-catalyzed asymmetric transfer hydrogenation of aromatic ketones in isopropanol. Good enantioselectivities up to 90% ee were observed.

• 出版日期2011-5