Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: Leucomalachite green

作者：Renwick Andrew^*; Leblanc Jean Charles; Setzer R Woodrow

来源：Food and Chemical Toxicology, 2010, 48: S75-S80.

DOI：10.1016/j.fct.2009.09.025

• Leucomalachite green
• Margin of exposure
• MOE

Leucomalachite green (LMG) is mutagenic and produces DNA-adducts in vivo. and is carcinogenic in rodent bioassays. Dose-response modelling of the data for hepatocellular adenomas and carcinomas in female mice gave a BMDL(10) of 20 mg/kg-bw/day. Limited data are available on the concentrations present in fish for human consumption. Human exposure estimates assumed that all consumed fish is contaminated with LMG. The calculated MoEs were 4,000,000 and 400,000 respectively for average and high exposure estimates.

• 出版日期2010-1