Continuous biocatalytic processing and synthesis: variations on a theme of "flow chemistry"

作者：Nidetzky Bernd^*; Bolivar Juan M

来源：Chimica Oggi-Chemistry Today, 2015, 33(4): 20-24.

• Continuous processing
• biotechnology
• biocatalysis
• biologics
• fine chemicals
• enzymes
• immobilization

Opportunities opened up by changing the biotechnological production from batch to continuous are explored actively in different sectors of industry. Continuous processing poses challenges for implementation and especially in the downstream part of the process where new technology developments may be necessary before fully continuous manufacturing can become reality. Continuous biocatalytic production is often implemented routinely, and large scale processes exist that are operated fully continuously. Continuous processing with soluble and insoluble (immobilized) enzymes is possible using suitable reactor design. Processing in microstructured flow reactors could play a role in specialized applications.

• 出版日期2015-8