A Convenient Synthesis of Novel Functionalized Pyrimido[5 ',4 ':4,5]thieno[3,2-c]pyridazines and Related Fused Systems

作者：Aly A A^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2008, 183(12): 3079-3096.

DOI：10.1080/10426500802060040

• Antimicrobial activities
• pyrimidothienopyridazines
• pyridazinothienotriazines
• pyridothienopyridazines
• thieno[3
• 2-c]pyridazine

Possible approaches to the synthesis of functionalized, pyrimido[5',4':4,5]thieno [3,2-c]pyridazines 2-18, pyridazino[3',4':4,5]thieno[2,3-d]triazines 19, 20a,b and pyrido[3',2':4,5]thieno[3,2-c]pyridazines 22a,b are described. The sequence involves the heterocyclization of 6-amino-1,3-diphenyl-1,4-dihydrothieno[3,2-c]pyridazine-7-carboxamide (1) with appropriate reagents. The antimicrobial activity of some the newly synthesized compounds was examined. All tested compounds proved to be active as antibacterial and antifungal agents.

• 出版日期2008