SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

作者：Aoki Asako; Ozaki Kouichi; Sato Hiroshi; Takahashi Atsushi; Kubo Michiaki; Sakata Yasuhiko; Onouchi Yoshihiro; Kawaguchi Takahisa; Lin Tsung Hsien; Takano Hitoshi; Yasutake Masahiro; Hsu Po Chao; Ikegawa Shiro; Kamatani Naoyuki; Tsunoda Tatsuhiko; Juo Suh Hang H; Hori Masatsugu; Komuro Issei; Mizuno Kyoichi; Nakamura Yusuke; Tanaka Toshihiro^*

来源：Journal of Human Genetics, 2011, 56(1): 47-51.

DOI：10.1038/jhg.2010.141

• association
• genome
• myocardial infarction
• SNP

Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P = 5.3 x 10(-13), odds ratio = 0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI. Journal of Human Genetics (2011) 56, 47-51; doi:10.1038/jhg.2010.141; published online 25 November 2010

• 出版日期2011-1
• 单位河北医科大学