ANTIFUNGAL POTENTIAL OF ESSENTIAL OIL AND ETHANOL EXTRACTS OF LONICERA JAPONICA THUNB. AGAINST DERMATOPHYTES

作者：Rahman Atiqur; Al Reza Sharif M; Siddiqui Shah Alam; Chang Taehyun; Kang Sun Chul^*

来源：EXCLI Journal, 2014, 13: 427-436.

• Lonicera japonica Thunb.
• essential oil
• ethanolic extracts
• antidermatophytic activity
• skin infectious fungal pathogens

The antifungal potential of essential oil and ethanolic leaf extracts of Lonicera japonica Thunb. was evaluated for controlling the growth of dermatophytes. The oil (1,000 ppm) and extracts (1,500 ppm) of L. japonica revealed 55.1-70.3 % and 40.1-65.5 % antidermatophytic effect against Microsporum canis KCTC 6348, 6349, 6591, Trichophyton rubrum KCTC 6345, 6352, 6375, Trichophyton mentagrophytes KCTC 6077 and 6085, respectively, along with their respective minimum inhibitory concentrations ranging from 62.5-500 and 1251,000 mu g/ml. Also, the oil had strong detrimental effect on spore germination of all the tested dermatophytes as well as concentration and time-dependent kinetic inhibition of M. canis KCTC 6348. The results demonstrated that L. japonica oil and extracts could be potential sources of natural fungicides to protect human and animals from fungal infections.

• 出版日期2014