The Effects of Time Lag and Cure Rate on the Global Dynamics of HIV-1 Model

作者：Ali, Nigar; Zaman, Gul^*; Abdullah; Alqahtani, Aisha M.; Alshomrani, Ali Saleh

来源：Biomed Research International, 2017, 2017: 8094947.

DOI：10.1155/2017/8094947

• CLEARANCE RATE
• VIRUS
• INFECTION
• CELLS
• DELAY

In this research article, a new mathematical model of delayed differential equations is developed which discusses the interaction among CD4 T cells, human immunodeficiency virus (HIV), and recombinant virus with cure rate. The model has two distributed intracellular delays. These delays denote the time needed for the infection of a cell. The dynamics of the model are completely described by the basic reproduction numbers represented by R-0, R-1, and R-2. It is shown that if R-0 < 1, then the infection-free equilibrium is locally as well as globally stable. Similarly, it is proved that the recombinant absent equilibrium is locally as well as globally asymptotically stable if 1 < R-0 < R-1. Finally, numerical simulations are presented to illustrate our theoretical results. Our obtained results show that intracellular delay and cure rate have a positive role in the reduction of infected cells and the increasing of uninfected cells due to which the infection is reduced.

• 出版日期2017
• 单位江苏大学