Size-controlled/Surface-Functionalized Polystyrene Nanospheres with Good Biocompatibility and High Encapsulation Efficiency of Cyclosporin A via Miniemulsion Polymerization in One Step

作者：Song, Xiaoli; Yang, Fangfang; Li, Ling; Zhu, Aiping^*

来源：Chinese Journal of Chemistry, 2016, 34(7): 720-726.

DOI：10.1002/cjoc.201600102

• polystyrene
• nanospheres
• biocompatibility
• drug delivery system
• cyclosporin A

In this paper, size-controlled and surface-functionalized RhB-labeled and Cyclosporin A (CsA)-loaded polystyrene (PS) nanospheres were successfully synthesized via miniemulsion polymerization. The biophysical properties of PEG functionalized PS nanospheres from protein adsorption, blood compatibility, cell compatibility and cell penetrability showed the nanoparticles with high biocompatibility. These results indicated that PEG modified PS nanospheres showed outstanding properties as low size distribution (0.164), high encapsulation efficiency (98.3%), long re-calcification time (50% than positive control), low hemolysis ratio (3.19%) and high cell viability (95.3%). This work could be used as a good drug delivery system for CsA.

• 出版日期2016-7
• 单位扬州大学