ASF1a enhances antiviral immune response by associating with CBP to mediate acetylation of H3K56 at the Ifnb promoter

作者：Liu, Zhaolong; Yang, Le; Sun, Yanxiang; Xie, Xiaofeng; Huang, Jianping^*

来源：Molecular Immunology, 2016, 78: 57-64.

DOI：10.1016/j.molimm.2016.08.008

• ASF1a
• CBP
• H3K56
• IFN-beta

ASF1a (anti-silencing function 1a), an evolutionarily conserved protein and a histone chaperone, is required for a variety of chromatin-mediated cellular processes. However, the function of ASF1a in innate immune response remains unclear. Here, we find that ASF1a is induced in Vesicular Stomatitis Virus (VSV)-infected macrophages in a manner that is dependent on IRF3 signal. ASF1a promotes VSV-triggered IFN-beta production, Moreover, acetylation of H3K56 increases at the ifnb promoter after VSV infection, which is dependent on ASFI a. Furthermore, we find ASF1a-mediated H3K56ac is dependent on the acetyltransferases activity of CREB binding protein (CBP) and the association between ASFI a and CBP. Therefore, our work provides a new insight into the antiviral mechanism that histone chaperone ASF1a-mediated H3K56ac modification promotes IFN-beta production.

• 出版日期2016-10
• 单位上海中医药大学