Antimicrobial and antiurease potential of Diorganotin(IV) Schiff bases

作者：Khan Shuja Abbas; Naeem Rehan; Hussain Shah; Ali Saqib; Muhammad Naveed; Hussain Zahid; Shujah Shaukat^*

来源：Pakistan Journal of Pharmaceutical Sciences, 2018, 31(4): 1399-1405.

• Organ tin (IV) Schiff base
• antibacterial activity
• antifungal activity
• antiurease assay

Six new diorganotin (IV) Schiff bases, [(CH3)(2)SnL] (I), [(C2H5)(2)SnL] (II), [(n-C4H9)(2)SnL] (III), [(C6H5)(2)SnL] (IV), [(CH2C6H5)(2)SnL] (V) and [(n-C8H17)(2)SnL] (VI) where L = N-(5-bromo-2-oxidobenzylidene)phenylacetohydrazide, were synthesized and characterized by elemental analysis, FT-IR, multinuclear NMR (H-1, C-13) and UV-visible spectroscopy. Spectroscopic studies indicate coordination of ligand to the diorganotin (IV) moieties via ONO donor sites generating a pentacoordinated tin center. The synthesized compounds were tested in vitro for antibacterial activity against Klebsiella pneumonia, Salmonella typhimurium, Escherichia coli, Aeromonas, Staphylococcus aureus, Vibrio cholerae, Pseudomonas aeruginosa, Shigella flexneri, and in vitro antifungal activity against Aspergillus nigar, Fusarium solani, Aspergillus fumigatus and Alternaria species. All the compounds were also screened for antiurease activity.

• 出版日期2018-7