An efficient, greener, and solvent-free one-pot multicomponent synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones

作者：Jalani Hitesh B; Pandya Amit N; Pandya Dhaivat H; Sharma Jayesh A; Sudarsanam V; Vasu Kamala K^*

来源：Tetrahedron Letters, 2012, 53(32): 4062-4064.

DOI：10.1016/j.tetlet.2012.05.104

• 3-Substituted-quinazolin-4(3H)ones
• 3-Substituted-thienopyrimidin-4(3H)ones
• Greener approach
• Formamidine
• One pot reaction

Herein, we report an efficient, greener, and solvent-free novel method for the synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones in a one-pot sequence using methyl anthranilate or 2-aminothiophene-3-carboxylate with N,N'-dimethyl formamide dimethyl acetal and various anilines. The driving force for this reaction is the removal of N,N'-dimethylamine by various anilines resulting in 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones.

• 出版日期2012-8-8